Priya, K (2009) Toxicity assessment of the medicinal plant Cyathula prostrata. Journal of Applied Biosciences, 13. pp. 681-687. ISSN 1997 – 5902

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Abstract

Objectives: To evaluate the potential toxicity of methanolic extracts of the medicinal plant Cyathula
prostrata.
Methodology and results: Methanolic extract of C. prostrata (MECP) were evaluated at rates of 50, 100,
150, 200 and 250 mg/kg/bw to assess its impact on biochemical indices of Swiss albino mice.
Hematological profile, biochemical assays, activities of liver marker enzymes, antioxidant potential and
histopathological examinations were compared between control and experimental animals. The changes in
biochemical parameters were statistically insignificant. The treated mice showed conspicuous toxic
symptoms only after 150 mg/kg. These observations were supported by histopathological examination of
liver and spleen sections.
Conclusion and application of findings: These results demonstrate that the methanolic extract of Cyathula
prostrata is not toxic and therefore it may be used safely in clinical trials.

Item Type: Article
Uncontrolled Keywords: Cyathula prostrata, marker enzymes, antioxidant, hematology, histopathology
Depositing User: Mr Team Mosys
Date Deposited: 26 Jul 2022 09:02
Last Modified: 26 Jul 2022 09:02
URI: http://ir.psgcas.ac.in/id/eprint/1362

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