Muneefa, KI and Victor Arokia Doss, D and Sowndarya, R (2017) Beneficial effect of hydroethanolic extract of Ocimum basilicum L on enzymic and non enzymic antioxidant in depression induced rats. Journal of Medicinal Plants Studies, 5 (3). pp. 185-188. ISSN 2320-3862

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The antidepressant activity of Ocimum basilicum L was studied by administrating plant low dose (250
mg/Kg of bw) and high dose (500 mg/kg of bw) in depression induced rats. Imipramine (30 mg/Kg of
bw) was selected as the standard drug which showed significant antidepressant activity. Hydroethanolic
extract was orally administered to experimental rats for 14 days after the induction of depression. The
status of depression was confirmed by using Forced Swimming Test (FST) in experimental rats. Enzymic
and non- enzymic antioxidant level were analysed in control and experimental groups. The results
showed that the extract decreased immobility time after the treatment. The level of enzymic and non -
enzymic antioxidants were increased significantly levels in the brain tissues of experimental groups. Thus
it may be concluded that Ocimum basilicum showed high propensity to improve the antioxidant status in
rats. Hence, the antioxidant effect may be the cardinal mechanism of Ocimum basilicum in antidepressant
activity. Further studies may elucidate the possibility of the commercial use of Ocimum basilicum for the
benefit of patients suffering from depression.

Item Type: Article
Uncontrolled Keywords: Ocimum basilicum, Antidepressant activity, forced swimming test (FST), Non-enzymic antioxidants, Enzymic antioxidants
Depositing User: Mr Team Mosys
Date Deposited: 12 Aug 2022 04:53
Last Modified: 12 Aug 2022 04:53

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