Vijayakumar, G and Boopathi, G and Elango, M (2019) In vitro cytotoxic efficacy of PEG encapsulated manganese-doped zinc oxide nanoparticles on hepatocellular carcinoma cells. MATERIALS TECHNOLOGY. ISSN 1753-5557

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Abstract

The present study investigates the in vitro cytotoxic efficacy of polymer encapsulated bare and
Mn-doped ZnO nanoparticles against human liver carcinoma Huh7 cell lines. PEG capped bare
and Mn (2.0, 2.5 and 3.0 wt%) doped ZnO nanoparticles were synthesised through chemical
precipitation method. The structural and morphological interpretations of the prepared nanoparticles were carried out using X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM)
techniques. Optical absorption, emission properties and functional group analysis were carried
out using UV-Vis, PL and FTIR techniques. The XRD results confirmed the hexagonal wurtzite
crystal structure of nanoparticles with an average particle size of 17.19 nm. The anticancer ability
of the prepared samples against the human liver carcinoma cell line Huh7 was investigated by
studying the cell penetration, cell viability and ROS generation mechanisms.

Item Type: Article
Uncontrolled Keywords: ZnO nanoparticles; anticancer activity; ROS generation
Divisions: PSG College of Arts and Science > Department of Physics
Depositing User: Mr Team Mosys
Date Deposited: 21 Oct 2022 03:59
Last Modified: 21 Oct 2022 03:59
URI: http://ir.psgcas.ac.in/id/eprint/1615

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