KRISHNAMOORTHY, B S (2022) BIOLOGICAL STUDIES OF 4-AMINO BENZAMIDE DERIVED 1,2,3-TRIAZOLE LINKED CHALCONE AND ITS PYRAZOLINE DERIVATIVES. Asian Journal of Pharmceutical and Clinical Research, 15 (9). pp. 94-97. ISSN 2455-3891

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Abstract

Objectives: The present work planned to investigate the anti-bacterial, anti-fungal, and anti-oxidant activity against 4-amino benzamide derived
1,2,3-triazole linked chalcone and pyrazoline derivatives.
Methods: Anti-microbial activity for pyrazoline derivatives was accomplished by serial dilution method. The test organisms of bacterial strains
were (Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas fluorescence) and the fungal cultures (Aspergillus niger,
Aspergillus terreus, and Trichoderma harzanium). The method used in the anti-oxidant activity is 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric
oxide scavenging method.
Results: All the compounds showed good to moderate anti-bacterial and anti-fungal activities. The results of IC50 values showed lower potent
inhibition activity with DPPH and higher potent inhibition activity in nitric oxide scavenging method.
Conclusion: All the compounds had exhibited capricious growth inhibitory effect on anti-bacterial, anti-fungal, and anti-oxidant activities.

Item Type: Article
Uncontrolled Keywords: 1,2,3-triazole, Chalcone, Pyrazoline, Anti-microbial activity and anti-oxidant activity.
Divisions: PSG College of Arts and Science > Department of Chemistry
Depositing User: Mr Team Mosys
Date Deposited: 01 Apr 2023 03:53
Last Modified: 01 Apr 2023 03:53
URI: http://ir.psgcas.ac.in/id/eprint/1836

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