Rajiv, Periakaruppan and Naveen, Kanna Duraisamy (2023) Production and Characterization of Azadirachta indica‑Mediated SiO2 Nanoparticles and an Evaluation of Their Antioxidant and Antimicrobial Activities. Silicon.

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Abstract

Azadirachta indica leaf extract was used in the current study to create silicon dioxide (SiO2) nanoparticles securely.
The unique aspect of this research is to utilize the biomass of A. indica as a capping, reducing, and stabilizing agent to
produceSiO2 nanoparticles with potential antioxidant activity. The size, functional groups, shape, purity, and stability of the
as-produced nanoparticles were analyzed using spectroscopic and microscopic assessments. In addition, the antioxidant and
antimicrobial activity were determined by DPPH assay and agar well difusion method. As-synthesized SiO2 nanoparticles
were spherical, extremely stable, and amorphous nanoparticles with an average size of 22 nm. FT-IR analysis reveals that the
occurrence of Si–O confrms the formation of SiO2 nanoparticles. The purity of silicon dioxide nanoparticles wa sinvestigated
by EDX analysis through the presence of Si and O. Thermal stability was determined and investigated by TGA analysis.
DPPH analysis and Agar well difusion assay confrmed that A. indica-mediated SiO2 nanoparticles show good antioxidant
and antimicrobial activity. The end product of biogenic SiO2 nanoparticles may be useful for the formulation of new drugs.

Item Type: Article
Uncontrolled Keywords: Azadirachta indica · SiO2 nanoparticles · FTIR · TGA · Antioxidant · Antimicrobial activity
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 03 Jul 2023 09:15
Last Modified: 03 Jul 2023 09:15
URI: http://ir.psgcas.ac.in/id/eprint/1941

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