Mahalingam, S M (2021) Design of a Near Infrared Fluorescent Ureter Imaging Agent for Prevention of Ureter Damage during Abdominal Surgeries. Molecules, 26 (3739). pp. 2-11.

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The inadvertent severing of a ureter during surgery occurs in as many as 4.5% of colorectal
surgeries. To help prevent this issue, several near-infrared (NIR) dyes have been developed to assist
surgeons with identifying ureter location. However, the majority of these dyes exhibit at least some
issue that precludes their widespread usage such as high levels of uptake in other tissues, overlapping
emission wavelengths with other NIR dyes used for other fluorescence-guided surgeries, and/or
rapid excretion times through the ureters. To overcome these limitations, we have synthesized and
characterized the spectral properties and biodistribution of a new series of PEGylated UreterGlow
derivatives. The most promising dye, UreterGlow-11 was shown to almost exclusively excrete
through the kidneys/ureters with detectable fluorescence observed for at least 12 h. Additionally,
while the excitation wavelength is similar to that of other NIR dyes used for cancer resections,
the emission is shifted by ~30 nm allowing for discrimination between the different fluorescenceguided surgery probes. In conclusion, these new UreterGlow dyes show promising optical and
biodistribution characteristics and are good candidates for translation into the clinic.

Item Type: Article
Uncontrolled Keywords: ureter imaging; fluorescence-guided surgery; near-infrared dye; PEG pharmacokinetics
Depositing User: Mr Team Mosys
Date Deposited: 23 Jun 2022 03:14
Last Modified: 23 Jun 2022 03:14

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