Sakthivel, K M (2019) Ki-67 protein as a tumour proliferation marker. Clinica Chimica Acta, 491. pp. 39-45. ISSN 0009-8981

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Newer treatment strategy based on proliferative nuclear marker Ki-67 targeted therapy holds promise for
prioritized/personalized treatment options with regard to improved survival and outcome in patients with renal
cancer. Over the past decade, the importance of Ki-67 in prognosis of breast cancer has been widely studied,
however very few studies and literatures are available in the context of renal cancer which has an increasing
incidence internationally. The focus of this present review is to fill the gaps pertaining to its prognosis and
management with newly understood mechanisms of targeted interventions. Recent breakthrough discoveries
have highlighted the correlation of Ki-67 expression to stage and metastatic potential in renal tumours. A better
understanding of molecular structure and different protein domains along with its regulation will provide evidence for precise target thereby controlling the proliferation rate correlated with decrease in the Ki-67 protein
levels. Therapies targeting Ki-67 is still in the preclinical stage, besides its diagnostic and/or prognostic significance, a better understanding of targeted strategical studies is required for extrapolation to the clinical use.
Current understanding of the associated molecular pathways and the precise role of Ki-67 could streamline the
basis for predicting renal cancer outcome.

Item Type: Article
Uncontrolled Keywords: Proliferation Ki-67 Renal cancer Breast cancer Targeted therapy Diagnosis
Depositing User: Mr Team Mosys
Date Deposited: 21 Jul 2022 06:00
Last Modified: 21 Jul 2022 06:00

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