Ragavan, B (2019) Antihyperlipidemic effect of Kaempferia galanga in streptozotocin-induced diabetic rats. Drug Invention Today, 14 (3). pp. 433-437. ISSN 0975-7619

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Background: Diabetes mellitus is one of the worldwide increasing problems characterized by metabolic deregulation.
One of the major factors contributing to cardiovascular risk in patients with Type 2 diabetes is abnormalities of lipoprotein
metabolism. Due to various side effects caused by available drugs, the search for new antidiabetic and antihyperlipidemic
drugs from herbal plants has become essential. Aim: The present study was carried out to evaluate the antihyperlipidemic
potential of hydroethanolic extract of Kaempferia galanga rhizome in streptozotocin (STZ)-induced diabetic rats.
Materials and Methods: Male albino Wistar rats (6 weeks old), weighing 170–200 g, were used for the present study.
Diabetes was induced by intraperitoneal injection of STZ at a dose of 60 mg/kg body weight (bw). Oral administration
of hydroethanolic extract of K. galanga rhizome at 250 mg/kg bw and 500 mg/kg bw was carried out for 28 days. Blood
was collected by cardiac puncture and the serum was separated and analyzed for biochemical parameters. Results: The
reports showed a significant reduction in the levels of protein, total cholesterol, phospholipids, triglyceride, very low-density
lipoproteins (LDL), and LDL compared to the diabetic group which was reverted to near-normal levels in treated groups.
The level of high-density lipoprotein cholesterol significantly increased in treated groups with the improvement of diabetic
dyslipidemia. Conclusion: The present findings infer that the rhizome extract is capable of controlling hyperlipidemia.
Further studies can be carried out to isolate the active compound for the management of diabetes-induced complications

Item Type: Article
Uncontrolled Keywords: Cholesterol, Diabetes, Hyperlipidemia, Kaempferia galanga, Lipid level, Streptozotocin
Depositing User: Mr Team Mosys
Date Deposited: 02 Aug 2022 05:18
Last Modified: 02 Aug 2022 05:18
URI: http://ir.psgcas.ac.in/id/eprint/1389

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