Victor Arokia Doss, D and Dharaniyambigai, KUBERAPANDIAN (2019) Effect of hydroethanolic extract of Piper betle in isoproterenol induced cardiac hypertrophy. INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES, 10 (4). pp. 3055-3062. ISSN 0975-7538

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Cardiac hypertrophy (CH) is a condition in which myocardial mass is increased
beyond the normal range due to irreversible ϑibrotic events that lead to various complication like ventricular chamber dilation, thinning of the internal
walls and extensive myocardial damage. In this study, the cardioprotective
potential of the hydro-ethanolic extract of Piper betle (P. betle) was evaluated
against cardiac hypertrophy induced by isoproterenol in male albino Wistar
rats. Isoproterenol (10 mg/kg b.w., i.p., 7 days) induced cardiac hypertrophy in experimental rats which were simultaneously treated with the standard drug losartan (50 mg/ kg b.w., oral., 7 days) and hydro-ethanolic extract
of P. betle (200 mg/kg b.w., oral., 7 days). Biochemical estimations revealed
increased levels of glucose, protein, albumin, lipid proϑiles (total cholesterol,
HDL and triglycerides), urea, creatinine, cardiac maker enzymes (SGOT; SGPT
and LDH), reduced enzymic antioxidants (SOD, CAT, GPx) and serum were
observed during CH which were reciprocated to normal when treated with
plant extract. Histopathological analysis of the heart tissue (left ventricles)
showed repairment of cellular architecture with reduced stiffened cell layers
and necrosis in plant extract administered rats thereby indicating the antihypertrophic potential of P. betle.

Item Type: Article
Uncontrolled Keywords: Cardiac hypertrophy, Isoproterenol, Losartan, Piper betle
Depositing User: Mr Team Mosys
Date Deposited: 12 Aug 2022 04:34
Last Modified: 12 Aug 2022 04:34

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