Jeevanandam, Madesh (2021) Mitochondrial dysfunction: A hidden trigger of autism? Genes & Diseases, 8 (5). pp. 629-639. ISSN 2352-3042

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Abstract Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with
no precise etiology. Deficits in cognitive functions uncover at early stages and are known to
have an environmental and genetic basis. Since autism is multifaceted and also linked with
other comorbidities associated with various organs, there is a possibility that there may be
a fundamental cellular process responsible for this. These reasons place mitochondria at the
point of interest as it is involved in multiple cellular processes predominantly involving metabolism. Mitochondria encoded genes were taken into consideration lately because it is inherited maternally, has its own genome and also functions the time of embryo development.
Various researches have linked mitochondrial mishaps like oxidative stress, ROS production
and mt-DNA copy number variations to autism. Despite dramatic advances in autism research
worldwide, the studies focusing on mitochondrial dysfunction in autism is rather minimal,
especially in India. India, owing to its rich diversity, may be able to contribute significantly
to autism research. It is vital to urge more studies in this domain as it may help to completely
understand the basics of the condition apart from a genetic standpoint. This review focuses on
the worldwide and Indian scenario of autism research; mitochondrial abnormalities in autism
and possible therapeutic approaches to combat it.

Item Type: Article
Uncontrolled Keywords: Autism; Copy number variation (CNV); Mitochondria encoded genes; Neurodevelopmental disorder; World-wide scenario
Depositing User: Mr Team Mosys
Date Deposited: 14 Mar 2023 09:30
Last Modified: 14 Mar 2023 09:30

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