Rajiv Periakaruppan (2025) Biogenic Synthesis and Characterization of Calcium Oxide Nanoparticles Using Bark Extract of Syzygium cumini and an Evaluation of Their Cytotoxicity and Wound Healing Properties. Biogenic Synthesis and Characterization of Calcium Oxide Nanoparticles Using Bark Extract of Syzygium cumini and an Evaluation of Their Cytotoxicity and Wound Healing Properties, 197. pp. 6592-6603.

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Abstract

The current study focuses on synthesis of biogenic calcium oxide nanoparticles (CaO NPs)
using the bark extract of Syzygium cumini, through green chemistry approach. It deals with
the development of CaO NPs using Syzygium cumini bark, which is ethnomedicinally rel�evant and has a multitude of applications. The green synthesis technique ensures sustain�ability by the use of natural reducing agents and less release of hazardous wastes. Synthe�sized CaO NPs were characterized by X-ray difraction (XRD), Fourier transform infrared
spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spec�troscopy (EDX), and thermogravimetric analysis (TGA). The XRD analysis confrmed a
cubic crystalline structure with an average particles size ranging from 48 to 52 nm. SEM
and EDX analysis showed a spherical morphology with some aggregation, while elemental
analysis confrmed the presence of Ca, O, Na, and C. FTIR spectroscopy identifed func�tional groups that acted as capping and stabilizing agents. The thermal stability of CaO
NPs was determined by TGA with loss of weight due to moisture evaporation and organic
decomposition. Cytotoxicity assays showed dose–response manner, 88.37% cell viability
at 20 µg and 61.97% at 100 µg, which indicates probable biomedical applications. Scratch
assay demonstrated the nanoparticle ability to promote wound healing and tissue regenera�tion. S. cumini-mediated CaO NPs can be translated to potential biomedicine applications
such as wound healing, antimicrobial agents, and drug delivery

Item Type: Article
Uncontrolled Keywords: Syzygium cumini · Bark extract · Biogenic synthesis · Nanoparticles · Calcium oxide
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Dr. B Sivakumar
Date Deposited: 06 Apr 2026 05:51
Last Modified: 06 Apr 2026 05:51
URI: https://ir.psgcas.ac.in/id/eprint/2773

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