Bellie Sundaram Krishnamoorthy (2025) Nickel-catalyzed rearrangement of aldoximes or aldehyde into primary amides. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2026 (2). pp. 647-653.

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Abstract

The synthesis of primary amides from aldehydes was carried out using the commercially available catalyst
[NiCl2(PPh3)2] without the use of any chelating agents, additives, or harsh reagents in a one-pot process.
We investigated the effects of catalyst screening, reaction time, solvent, bases, and catalyst loading for this
reaction. The methodology demonstrated broad substrate compatibility, proceeding efficiently with a
diverse range of aldehydes. These included electron-rich, electron-deficient, halogenated, ring-extended,
and aliphatic aldehydes, as well as substrates featuring extended conjugation and hetero-aromatic
frameworks. A nickel catalytic system was developed, and the amides were obtained in good to excellent
yields through the reaction of aldehydes and hydroxylamine hydrochloride in toluene with NaHCO3. Finally,
a plausible mechanism involving Ni(II)/(III) species is proposed and elucidated through DFT calculations at
the BP86/Def2-TZVP level.

Item Type: Article
Divisions: PSG College of Arts and Science > Department of Chemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 19 Jun 2026 05:47
Last Modified: 19 Jun 2026 05:47
URI: https://ir.psgcas.ac.in/id/eprint/2935

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