Rajan Radha Rasmi and Loganathan Chandramani Priya Dharshini and Kunnathur Murugesan Sakthivel (2025) Targeting the redox neuroinflammatory nexus: insights into Alzheimer’s and Parkinson’s diseases. Inflammopharmacology.

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Abstract

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s, are characterized by the progressive deterioration of
neuronal structure and function within the central and peripheral nervous systems. Among the multifactorial mechanisms
implicated in their pathogenesis, oxidative stress and chronic neuroinflammation have emerged as pivotal contributors. An
imbalance in redox homeostasis, marked by excessive generation of reactive oxygen species (ROS) and impaired antioxidant
defenses, leads to sustained activation of inflammatory pathways and exacerbation of neuronal injury. This intricate interplay,
known as the redox–neuroinflammatory nexus, constitutes a central axis in the onset and progression of neurodegeneration.
This review underscores the critical role of redox imbalance in neurodegenerative processes and provides a comprehensive
analysis of the oxidative stress and inflammation crosstalk in Alzheimer’s and Parkinson’s diseases, offering insights into
potential therapeutic targets.

Item Type: Article
Uncontrolled Keywords: Neurodegenerative disease · Alzheimer’s disease · Parkinson’s disease · Oxidative stress · Inflammation
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Dr. B Sivakumar
Date Deposited: 19 Jun 2026 07:08
Last Modified: 19 Jun 2026 07:08
URI: https://ir.psgcas.ac.in/id/eprint/2938

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