Muthukrishnan, P and Chithra Devi, D (2020) Antimicrobial efficacy of Nocardiopsis sp. MK MSt033 against selected multidrug resistant clinical microbial pathogens. Journal of Infection and Public Health, 13. pp. 1522-1532. ISSN 1876-0341

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Abstract

Background: Actinomycetes show an active role in microbial disease control and antimicrobial
metabolism production and were shown the greatest potentialities as sources of antimicrobial agents.
The past few decades, an extensive literature has accumulated on the production of bioactive compounds
from actinomycetes, particularily genus Streptomyces.
Methods: The actinomycetes were isolated with starch casein nitrate (SCN) agar medium. The prospective
isolate was subjected to antimicrobial metabolites production. Further, the bio-extract was evaluated
their biological properites by agar well diffusion assay and finally the extract was anaylized through
GC–MS.
Results: In the present study, isolated 9 actinomycetes and the isolates were examined for their antifungal
activities. Of these nine isolates, the isolate MK MSt033 picked out from the rest, hences, it showed
significant control towards the selected microbial pathogens. The prospective strain MK MSt033 was
determinedas Nocardiopsis sp. The straindisplayedeffective antimicrobial activities against bothbacterial
and fungal pathgoens such as Escherichia coli, Staphylococcus aureus, Pencillium sp., and Aspergillus flavus
respectively. Subsequently the chemical nature of the compounds produced by the potential isolate
MK MSt033 and it was successfully determined by GC–MS and it were 18 compounds with different
retention time.
Conclusion: The identified isolate Nocardiopsis sp. MK MSt033 exhibited potential antimicrobial activities against selected microbial pathogens. Thus, the soil inhabiting Nocardiopsis sp. has explored for
pharmaceutically active compounds with promising medical applications

Item Type: Article
Uncontrolled Keywords: Nocardiopsis,Antimicrobial, FTIR analysis, Antifungal, GC–MS
Divisions: PSG College of Arts and Science > Department of Microbiology
Depositing User: Mr Team Mosys
Date Deposited: 07 Jul 2022 06:10
Last Modified: 07 Jul 2022 06:10
URI: http://ir.psgcas.ac.in/id/eprint/1281

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