Sangeetha, B A and Shobana, CS and Suresh, S and Abirami, B (2020) In-vitro assessment of first-line antifungal drugs against Aspergillus spp. caused human keratomycoses. Journal of Infection and Public Health, 13. pp. 1907-1911. ISSN 1876-0341

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Abstract

Background and objectives: Aspergillus keratitis are in the increasing trend and reported as the second
most common cause of mycotic keratitis in developing countries. The present study was designed to
isolate, identify Aspergillus spp. from the keratits/corneal ulcer patients attending a tertiary care eye
hospital, Coimbatore, South India and to assess the minimum inhibitory concentrations (MICs) against
ten clinically used first-line antifungal drugs.
Methods: A total of seventy-three Aspergillus strains isolated from corneal scrapings were included and
assessed for a period of one year. All isolates were identified up to the species level by morphological
observations. Antifungal drug susceptibilities were determined against a standard panel of antifungal
agents.
Conclusions: Five different species of aspergilli, A. flavus (n=53), A. fumigatus (n=14), A. terreus (n=9), A.
tamarii (n=6) and A. niger (n=3) were identified based on morphological features. Minimum inhibitory
concentration analyses indicated that, voriconazole, natamycin, itraconazole, clotrimazole, econazole
followed by ketoconazole shall be the order of choices for the effective treatment for Aspergillus keratitis.

Item Type: Article
Uncontrolled Keywords: Keratitis Aspergillus Minimum inhibitory concentration Natamycin Voriconazole
Divisions: PSG College of Arts and Science > Department of Microbiology
Depositing User: Mr Team Mosys
Date Deposited: 07 Jul 2022 06:17
Last Modified: 07 Jul 2022 06:17
URI: http://ir.psgcas.ac.in/id/eprint/1282

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