Brindha, Durairaj and Manish, R (2019) Zebrafish: An In Vivo Model for the Study of Therapeutic Targets of Epilepsy. International Society for Neuro Regulations Research, 6 (4). pp. 190-196.

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Abstract

Epilepsy is a common neurological disorder due to excessive brain cell activity. It is characterized by
unpredictable seizures resulting in cognition. The release of abnormal electric discharge in the regions of the
brain causes epileptic seizures. Neurotransmitters play an important role in normal functioning of the brain and
thus alteration of these neurotransmitters are associated with epilepsy. Zebrafish model have recently become
a focus for various neurological disorders because of its high genetic similarity when compared with those of
humans. Zebrafish can be grown in large numbers and their embryos are optically clear allowing examination of
individual genes. This review will look at the utility of the zebrafish in the study of various therapeutic targets of
epilepsy such as GABA (gamma-aminobutyric acid), AMPA, NMDA (N-methyl-d-aspartate), histamine H3, and
phosphodiesters.

Item Type: Article
Uncontrolled Keywords: epilepsy; seizures; neurotransmitters; zebrafish; therapeutic targets
Depositing User: Mr Team Mosys
Date Deposited: 15 Jul 2022 04:46
Last Modified: 15 Jul 2022 04:46
URI: http://ir.psgcas.ac.in/id/eprint/1313

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