Sakthivel, K M (2019) Antiangiogenic, anti-inflammatory and their antioxidant activities of Turnera subulata Sm. (Turneraceae). Process Biochemistry, 89. pp. 71-80. ISSN 1359-5113

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Abstract

Turnera subulata is a substantial medicinal plant used in folk medicine to treat various ailments. The current
study was assess the total phenolic and flavonoid contents to evaluate the antioxidant and anti-inflammatory
activities of the sequentially extracted T. subulata plant samples. In vitro anti-angiogenic activity was evaluated
by chick chorioallantoic membrane (CAM) model for chloroform, ethyl acetate and ethanol extracts. The results
obtained revealed that total phenolic content of the chloroform extract (24.13 ± 0.27 mg/g) and total flavonoid
content (TFC) of the chloroform extract (22.28 ± 0.40 mg/g) were found to be suggestively higher than the
other extracts. A strong antioxidant property was observed for all the six extracts. A study anti-inflammatory
activity was observed in chloroform and ethanol extracts, with IC50 ranging from 79 ± 1.01 μg/mL to
81 ± 1.01 μg/mL for protein denaturation assay and from 74 ± 0.11 μg/mL to 76 ± 1.11 μg/mL for HRBC
membrane stabilization assay, respectively. The chloroform and ethanol extracts have exhibited good antiangiogenic property. Eventually, these results justified that the chloroform and ethanol extracts of T. subulata
with great antioxidant, anti-inflammatory and antiangiogenesis potentials could be promising candidates for the
development of a cost effective, potent anticancer drug with minimal side effects.

Item Type: Article
Uncontrolled Keywords: Turnerasubulata Antioxidant Anti-inflammatory Antiangiogenesis Chick chorioallantoic membrane (CAM)
Depositing User: Mr Team Mosys
Date Deposited: 21 Jul 2022 06:18
Last Modified: 21 Jul 2022 06:18
URI: http://ir.psgcas.ac.in/id/eprint/1330

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