Sakthivel, K M (2020) A novel Ag/carrageenan–gelatin hybrid hydrogel nanocomposite and its biological applications: Preparation and characterization. Journal of the Mechanical Behavior of Biomedical Materials, 115. ISSN Balasubramanian

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Abstract

A novel biohybrid hydrogel nanocomposite made of natural polymer carrageenan and gelatin protein were
developed. The silver nanoparticles were prepared using the carrageenan polymer as reduction and capping
agent. Here, the Ag/Carrageenan was combined with gelatin hydrogel using glutaraldehyde having a cross-link
role in order to create the biohybrid hydrogel nanocomposite. The manufactured composite performances were
anaylised by UV–visible spectroscopy, Fourier Transform infrared (FTIR) spectroscopy, Scanning Electron Microscopy (SEM), Energy dispersive X-ray (EDX) spectroscopy and Transmission Electron Microscopy (TEM)
methods. The swelling behaviour of the Ag/Carrageenan-gelatin hybrid hydrogel nanocomposite was also
analyzed. The antibacterial activity was tested against human pathogens viz. S. agalactiae 1661, S. pyogenes 1210
and E. coli. The bacterial cell wall damage of S. agalactiae 1661 was analyzed by scanning electron microscopy.
The cytotoxic assay was performed against the A549 lung cancer cells.

Item Type: Article
Uncontrolled Keywords: Biocompatibility Carrageenan Polysaccharide Capping agent Hydroge
Depositing User: Mr Team Mosys
Date Deposited: 22 Jul 2022 08:23
Last Modified: 22 Jul 2022 08:23
URI: http://ir.psgcas.ac.in/id/eprint/1338

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