Sakthivel, K M and Rasmia, Rajan Radha (2022) Role and regulation of autophagy in cancer. BBA - Molecular Basis of Disease. pp. 1-22. ISSN 0925-4439

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Abstract

Autophagy is an intracellular self-degradative mechanism which responds to cellular conditions like stress or
starvation and plays a key role in regulating cell metabolism, energy homeostasis, starvation adaptation,
development and cell death. Numerous studies have stipulated the participation of autophagy in cancer, but the
role of autophagy either as tumor suppressor or tumor promoter is not clearly understood. However, mechanisms
by which autophagy promotes cancer involves a diverse range of modifications of autophagy associated proteins
such as ATGs, Beclin-1, mTOR, p53, KRAS etc. and autophagy pathways like mTOR, PI3K, MAPK, EGFR, HIF and
NFκB. Furthermore, several researches have highlighted a context-dependent, cell type and stage-dependent
regulation of autophagy in cancer. Alongside this, the interaction between tumor cells and their microenvironment including hypoxia has a great potential in modulating autophagy response in favour to substantiate
cancer cell metabolism, self-proliferation and metastasis. In this review article, we highlight the mechanism of
autophagy and their contribution to cancer cell proliferation and development. In addition, we discuss about
tumor microenvironment interaction and their consequence on selective autophagy pathways and the involvement of autophagy in various tumor types and their therapeutic interventions concentrated on exploiting
autophagy as a potential target to improve cancer therapy.

Item Type: Article
Uncontrolled Keywords: Autophagy Homeostasis Cancer Hypoxia
Depositing User: Mr Team Mosys
Date Deposited: 22 Jul 2022 08:56
Last Modified: 22 Jul 2022 08:56
URI: http://ir.psgcas.ac.in/id/eprint/1342

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