Ragavan, B and Monisha, S (2017) Effect of polyherbal extract on TCA cycle enzymes and heart tissue histology in isoproterenol induced myocardial rats. Journal of Environmental Biology, 38. pp. 401-408. ISSN 2394-0379

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Abstract

Aim:
Methodology:
Results:
Interpretation:
Cardiovascular disease has become a universal cause of morbidity and largely contributes to
mortality in developed and developing countries. The present study aimed to evaluate the cardioprotective
role of polyherbal extract on isoproterenol induced myocardial infarction in Wistar albino rat model.
The rats were divided into eight groups each having six animals. Treatment I served as
control, Treatment II rats were administered isoproterenol, Treatment III and IV were pretreated with
polyherbal extract and received a subcutaneous injection of isoproterenol, Treatment V and VI were
pretreated orally with propranolol and received a subcutaneous injection of isoproterenol, Treatment VII
and VIII received polyherbal extract for 30 days. After cervical dislocation, the heart tissues were removed
and studied for TCA cycle and respiratory chain enzymes along with histopathological observation.
Isoproterenol induction exhibited significant (p<0.05) reduction in the enzyme activities of
mitochondrial TCA cycle. However, there was a significant (p<0.05) increase in polyherbal treated rats of -1 heart tissue homogenate. The effect of oral administration of polyherbal crude extract at 500 mg g b.wt. -1 -1 was found to have more effect than 250 mg g b.wt. Similarly, the standard drug propranolol 20 mg g b.wt.
treated rats also exerted an effective impact. The histological sections prepared from isoproterenol
hydrochloride treatment alone exhibited various degrees of focal lesions in several sections, consisting of
staining and fragmentation of muscle fibers with confluent retrogressive lesions. Animals treated with
polyherbal crude extract showed significant improvement in ISO-induced alterations such as vacuolar modifications,
edema, capillary dilation and leukocyte infiltration compared to ISO - administrated group.

Item Type: Article
Uncontrolled Keywords: Histopathology, Myocardial infarction, Polyherbal crude extract, TCA cycle enzymes
Depositing User: Mr Team Mosys
Date Deposited: 03 Aug 2022 03:12
Last Modified: 03 Aug 2022 03:12
URI: http://ir.psgcas.ac.in/id/eprint/1391

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