Rasmi, Rajan Radha (2020) Edible Sword Bean Extract Induces Apoptosis in Cancer Cells In Vitro and Inhibits Ascites and Solid Tumor Development In Vivo. NUTRITION AND CANCER.

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Abstract

Antitumor potential of edible sword bean (Canavalia gladiata (L.)) extract has been evaluated against Daltons lymphoma ascites (DLA) using in vitro and in vivo studies. Methanolic
extraction was carried out and in vitro studies were performed against both DLA and A549,
lung cancer cell lines. The results revealed that sword bean extract inhibited cell growth
and induced apoptosis as evidenced by cytotoxic assay, Hoechst 33342 staining and acridine
orange/ethidium bromide dual staining. In vivo studies performed on DLA induced solid as
well as ascitic tumors models showed administration of sword bean extract (10 mg/kg B.wt.)
could significantly inhibit ascitic and solid tumor development in mice. Therefore, our overall results revealed that C. gladiata treatment could significantly inhibit tumor development
and induce apoptosis in tumor cells.

Item Type: Article
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 03 Aug 2022 04:59
Last Modified: 03 Aug 2022 04:59
URI: http://ir.psgcas.ac.in/id/eprint/1398

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