Sakthivel, K M and Rasmi, Rajan Radha and Vishnupriya, Selvaraj and Priya Dharshini, L C (2020) Oxidative stress responsive transcription factors in cellular signalling transduction mechanisms. Cellular Signalling. pp. 1-9. ISSN 0898-6568

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Abstract

Oxidative stress results from the imbalances in the development of reactive oxygen species (ROS) and antioxidants defence system resulting in tissue injury. A key issue resulting in the modulation of ROS is that it alters
hosts molecular, structural and functional properties which is accomplished via various signalling pathways
which either activate or inhibit numerous transcription factors (TFs). Some of the regulators include Nuclear
erythroid-2 related factors (Nrf-2), CCAAT/enhancer-binding protein delta (CEBPD), Activator Protein-1 (AP-1),
Hypoxia-inducible factor 1(HIF-1), Nuclear factor κB (NF-κB), Specificity Protein-1 (SP-1) and Forkhead Box
class O (FoxO) transcription factors. The expression of these transcription factors are dependent upon the stress
signal and are sometimes interlinked. They are highly specific having their own regulation cellular events.
Depending upon the transcription factors and better knowledge on the type of the oxidative stress help researchers develop safe, novel targets which can serve as efficient therapeutic targets for several disease conditions

Item Type: Article
Uncontrolled Keywords: Oxidative stress Transcription factors Reactive oxygen species Cell signalling Therapeutic targets
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 03 Aug 2022 05:26
Last Modified: 03 Aug 2022 05:26
URI: http://ir.psgcas.ac.in/id/eprint/1402

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