Lavanya, K (2022) Anti-Diabetic Activity of Silver Nanoparticles Synthesized from the Hydroethanolic Extract of Myristica fragrans Seeds. Applied Biochemistry and Biotechnology.

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Abstract

Myristica fragrans, also known as nutmeg, is a spice that cures various diseases. This study
aimed to synthesize silver nanoparticles from a hydroethanolic extract of Myristica fragrans seeds (MFHE) and evaluate their anti-diabetic properties. To MFHE, AgNO3 solution was added and exposed to sunlight to produce silver nanoparticles from hydroethanolic seed extract of Myristica fragrans (MFHENP). The MFHENP was characterized by
numerous techniques. UV-visible spectroscopy confrmed the formation of silver nanoparticles by the absorption peak at 430nm. Scanning electron microscopy (SEM) studies
revealed the shape and size of the particles at the range of 50–60nm. Energy-dispersive
X-ray spectroscopy (EDX) disclosed the presence of silver ions. X-ray difraction spectrum
confrmed the crystalline nature of silver nanoparticles by the peak at 39°. FTIR analysis
revealed the functional groups present in MFHE as well as in MFHENP and zeta potential
analysis was found to be 14mV. Furthermore, in vitro anti-diabetic activity was investigated. MFHENP showed signifcant efciency against the inhibition of alpha-amylase and
alpha-glucosidase enzymes and also MFHENP retarded the glucose transport across the
membrane which is analyzed by glucose difusion and glucose uptake assays. Acarbose is
used as a standard for all these methods and MFHENP efciency proves their therapeutic
potential for the treatment of diabetes mellitus

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus · Myristica fragrans · Silver nanoparticles · Characterization · Anti-diabetic activity
Depositing User: Mr Team Mosys
Date Deposited: 10 Aug 2022 03:42
Last Modified: 10 Aug 2022 03:42
URI: http://ir.psgcas.ac.in/id/eprint/1425

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