Thangavelu, K and Victor Arokia DOSS (2013) ANTIDIABETIC ACTIVITY OF HYDROETHANOLIC LEAF EXTRACT OF GYMNEMA HIRSUTUM WIGHT & ARN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. International Journal of Pharmaceutical Sciences and Research, 4 (10). pp. 4027-4031. ISSN 0975-8232

[thumbnail of 1. 39 Vol. 4, Issue 10, October 2013, IJPSR, RA-2775, Paper 39 published.pdf] Text
1. 39 Vol. 4, Issue 10, October 2013, IJPSR, RA-2775, Paper 39 published.pdf - Published Version
Download (395kB)
Official URL: http:www.ijpsr.com

Abstract

The present study has investigated the hypoglycaemic
effect of oral administration of 50% ethanolic leaf extract of G.
hirsutum Wight & Arn in normal and Streptozotocin–induced diabetic
rats. Albino Wistar rats (190 to 220 gm) were induced diabetic
condition by administration of Streptozotocin (STZ) (55 mg/kg bw)
intraperitoneally. 50% ethanolic extract of G. hirsutum Wight & Arn
leaves (300 mg/kg bw /day) was orally administrated to normal and
STZ–induced diabetic rats (150, 300 and 450 mg/kg bw /day) for 30
days to determine hypoglycaemic and antihyperglycaemic activity.
Serum and tissue biochemical analysis including fasting blood sugar
level in normal and STZ–induced diabetic rats were investigated. Oral
administration of 50% ethanolic extract of G. hirsutum Wight & Arn
leaves (300 and 450 mg/kg bw/day) for 30 days exhibited a significant
(p<0.05) reduction in serum Glucose (88%), Total Cholesterol (80%),
Triglycerides (76%), HbA1c (75%) and in an oxidative stress. The
findings of investigation showed similar to those produced by
Glibenclamide (GB) at dose of 600 mg/kg bw /day for 30days
(positive control). Histopathological observation showed significant
improvement in the rats treated with G. hirsutum Weight & Arn leaf
extract. The results demonstrate that 50% ethanolic extract of G.
hirsutum leaves possess potent antidiabetic activity in STZ-induced
diabetic rats. Alkaloids, Flavanoids, Phenols and Tannins present in
this plant might be responsible for the effect.

Item Type: Article
Uncontrolled Keywords: Gymnema hirsutum (Gh), STZinduced diabetic rats, Glibenclamide (GB), Diabetic rats, Ethanolic extract and Hypoglycaemic activity
Depositing User: Mr Team Mosys
Date Deposited: 10 Aug 2022 04:50
Last Modified: 10 Aug 2022 05:53
URI: http://ir.psgcas.ac.in/id/eprint/1430

Actions (login required)

View Item
View Item
Altmetric