Thangavelu, K and Victor Arokia DOSS (2015) ANTIDIABETIC EFFECT OF 50% HYDROETHANOLIC EXTRACT OF ARISTALOCHIA BRACTEOLATA LAM LEAVES IN STREPTOZOTOCIN- INDUCED DIABETIC RATS. World Journal of Pharmaceutical Research, 4 (2). pp. 819-832. ISSN 2277– 7105

[thumbnail of 2. article_wjpr_1422702627.pdf] Text
2. article_wjpr_1422702627.pdf - Published Version
Download (664kB)
Official URL: http:www.wjpr.net

Abstract

The present work was aimed to evaluate the antidiabetic effect of 50%
hydroethanolic extract of Aristalochia bracteolata Lam. leaves on 36
adult male albino Wistar rats weighing about 190-220 gms. Rats were
divided into 6 groups of 6 rats in each. Group-I served as normal
control while diabetes was induced in Group-II, III, IV, V and VI using
Streptozotocin at a dose of 55 mg/kg bw by intraperitonial injection.
After induction of diabetes Gtoup – II served as diabetic control. Group
– VI rats were treated with 600 µg/kg bw/day of standard drug
(Glibenclamide) while Group – III, IV and V rats were orally
administred with 50% hydroethanolic leaf extract of Aristalochia
bracteolata Lam. at the doses of 150, 300 and 450 mg/kg bw/day
respectively for 28 days. To determine hypoglycemic effect of 50%
hydroethanolic leaf extract of A. bracteolata Lam., blood and tissue
biochemical parameters were assayed in normal, diabetic control and treated groups. Oral
administration of 50% hydroethanolic extract of A. bracteolata Lam. leaves for 28 days
exhibited a significant (p<0.05) antidiabetic effect similar to those produced by Glibenclamide
at a dose of 600 µg/kg bw/day for 28 days. This study also revealed potent antioxidant effect
of 50% hydroethanolic leaf extract of A. bracteolata Lam. 9 major compounds form the leaf
extract were identified through GC-MS analysis

Item Type: Article
Uncontrolled Keywords: Leaf extract of Aristalochia bracteolata Lam., Streptozotocin (STZ), Glibenclamide (GB) and antidiabetic effect
Depositing User: Mr Team Mosys
Date Deposited: 10 Aug 2022 04:54
Last Modified: 10 Aug 2022 05:56
URI: http://ir.psgcas.ac.in/id/eprint/1431

Actions (login required)

View Item
View Item
Altmetric