Thangavelu, K (2016) IN VIVO, IN VITRO AND IN SILICO ANTI-DYSMENORRHEA STUDIES OF A. BRACTEOLATA LAM. LEAF EXTRACT AND ITS MOLECULAR DOCKING. World Journal of Pharmacy and Pharmaceutical Sciences, 5 (4). pp. 1843-1856. ISSN 2278 – 4357

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Abstract

Menstruation is the periodic discharge of blood and the endometrium
from the uterus and vagina with a painful experience. The pain can
vary from woman to woman, for some women the pain is debilitating.
Painful menstruation is known as Dysmenorrhea which literally means
“difficult menstruation”. Women with menstrual cramps had high
levels of Prostaglandin F2 alpha (PGF2α) receptor. Prostaglandin F2
alpha is made by the uterus to stop Progesterone production. NSAIDs
have been found to decrease menstrual flow, which may reduce
menstrual pain. Herbal or natural remedies are more effective than
NSAIDs for reducing menstrual disorders. Aristolochia bracteolata
Lam. is a shrub distributed throughout India, belongs to the family
Aristolochiaceae. A.bracteolata Lam. is proved to have antioxidant, potent antimicrobial,
antidiabetic and antihelminthus properties. The results indicates that, regular treatment of
normal rats with A.bracteolata Lam. leaf extracts improve hematological parameters. In-vitro
studies revealed that it has got relaxation property. In- silico screening (Docking analysis)
proved that the leaf extract has got four bioactive compounds act against PGF2α receptor. Present study shows the potential for replacement of synthetic drugs by the use of natural
extract.

Item Type: Article
Uncontrolled Keywords: Menstruation, Dysmenorrhea, PGF2α receptor, A. bracteolata Lam. leaf extract.
Depositing User: Mr Team Mosys
Date Deposited: 10 Aug 2022 05:10
Last Modified: 10 Aug 2022 05:54
URI: http://ir.psgcas.ac.in/id/eprint/1433

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