Victor Arokia Doss, D (2019) Evaluation of Anti-hypertrophic Potential of Enicostemma littorale Blume on Isoproterenol Induced Cardiac Hypertrophy. Ind J Clin Biochem.

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Abstract

The main objective of this study is to evaluate
the anti-hypertrophic potential of the aqueous extract of
Enicostemma littorale (E. littorale) against isoproterenol
induced cardiac hypertrophic rat models (male albino
Wistar rats) through biochemical investigations. Aqueous
extract of E. littorale known for various beneficial properties was administered (100 mg/kg, 12 days, oral) to isoproterenol (ISO) induced cardiac hypertrophic rats (low
ISO—60 mg/kg, 12 days and high ISO—100 mg/kg,
12 days, subcutaneous) and were compared with group that
was treated with the reference drug, Losartan (10 mg kg,
administered for 12 days, oral). The anti-hypertrophic
effect of E. littorale was evaluated by analysing the morphometric indices of the heart, ECG tracings, changes in
blood biochemical parameters viz., serum glucose, serum
total protein, serum albumin, lipid profile, cardiac specific
enzymes (SGOT, SGPT and LDH) and histopathological
examination of the heart tissue. The results fundamentally
revealed that the plant extract efficiently ameliorated cardiac hypertrophy induced by ISO injected in experimental
rats. The outcomes of biochemical investigations of this
study highlighted the association between the hypertrophic
b-adrenergic receptor signalling (b-AR) and the 50 AMPactivated protein kinase (AMPK)—peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1a) axis in the metabolism of cardiac fibrosis and hypertrophy. This b-AR/AMPK-PGC1a signalling stem can
serve as a key target in ameliorating cardiac hypertrophy
through focus on its principal regulators. To add, we alsopropose that the glycoside, swertiamarin present in this
plant with the reported anti-fibrotic potential in liver can be further isolated and evaluated for its anti-hypertrophic
potential to treat cardiac hypertrophy.

Item Type: Article
Uncontrolled Keywords: Cardiac hypertrophy Cardiac fibrosis Isoproterenol Enicostemma littorale Swertiamarin Anti-hypertrophic effect.
Depositing User: Mr Team Mosys
Date Deposited: 12 Aug 2022 03:26
Last Modified: 12 Aug 2022 03:26
URI: http://ir.psgcas.ac.in/id/eprint/1444

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