Victor Arokia Doss, D and Sowndarya, R and Shalini, A Screening of Antidepressant Activity of Solanumnigrum. PSGCAS Search: A Journal of Science and Technology, 3 (2). pp. 63-67. ISSN 2349 – 5456

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Abstract

Solanumnigrum, black night shade contains alkaloid as its major component and its antidepressant like effect
has been previously demonstrated in some earlier research works. The purpose of this study was to explore the
possible contribution of Solanumnigrumin the antidepressant like effect of the serotonergic system in rats. Hydroethanolic extract of Solanumnigrumwas quantified for phenolic content by Folin-Ciocalteau’s method. Chronic
unpredictable mild stress (CUMS) was employed to induce stress in rats. Solanumnigrum (50 and 100 mg/kg, body
weight) and flouxetine (20mg/kg, body weight) were administered during the 21 day stress exposure period.
Antidepressant activities of Solanumnigrumwere assessed in open field exploratory and behavioural despair
paradigms, respectively. Our results indicate thatSolanumnigrumpossess anti-stress and moderate anxiolytic activity
which may be due, in part, to its antioxidant effect.

Item Type: Article
Uncontrolled Keywords: :Solanumnigrum, antidepressant effect, serotonergic system, flouxetine, anti-stress and anxiolytic activity.
Depositing User: Mr Team Mosys
Date Deposited: 12 Aug 2022 05:41
Last Modified: 12 Aug 2022 05:41
URI: http://ir.psgcas.ac.in/id/eprint/1453

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