Victor Arokia Doss, D and Nithyanand, P and Sowndarya, R (2016) Antidepressant Effect of Plectranthus amboinicus on Chronic Unpredictable Mild Stress Induced Rats. International Journal of Pharmacy & Pharmaceutical Research, 6 (2). pp. 377-382. ISSN 2349-7203

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Abstract

Plectranthus amboinicus contains flavonoids, alkaloid and
terpenoids as its major component. The purpose of the study is to explore the antidepressant activity of hydroethanolic extract of Plectranthus amboinicus leaf in rats. Chronic unpredictable mild stress (CUMS) was employed to induce stress in rats. Plectranthus amboinicus (200mg/kg, body weight) and Fluoxetine (20mg/kg, body weight) were administered during the 28 day stress exposure period. Antidepressant activity of ethanolic extract of leaf of Plectranthus amboinicus was investigated by using forced swim test (FST). Enzymatic antioxidants such as SOD, GPx, GSH and non enzymatic antioxidants such as vitamin C and lipid peroxidation show the significant increase and improved scavenging activity in treated rats when compared to depressed rats. So, it was concluded that
Plectranthus amboinicus possesses potential antidepressant
which may be due to its antioxidant effect.

Item Type: Article
Uncontrolled Keywords: Plectranthus amboinicus, Antidepressant activity, Forced swim test
Depositing User: Mr Team Mosys
Date Deposited: 12 Aug 2022 05:51
Last Modified: 12 Aug 2022 05:51
URI: http://ir.psgcas.ac.in/id/eprint/1454

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