Mobika, J and Rajkumar, M and Nithya Priya, V and Linto Sibi, S P (2020) Substantial effect of silk fibroin reinforcement on properties of hydroxyapatite/silk fibroin nanocomposite for bone tissue engineering application. Journal of Molecular Structure. pp. 1-8. ISSN 0022-2860

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Abstract

Nano-biocomposites that mimics bone’s extracellular matrix with hydroxyapatite as an inorganic and
silk fibroin as organic phase for three different ratios via a simple in-situ co-precipitation method have
been synthesized. The silk fibroin, a biodegradable polymer from cocoons of Bombyx mori silkworm were
extracted by employing a chemical-free High-Temperature High-Pressure method as a degumming route.
Then followed by the regeneration process which was done by using calcium chloride-formic acid solvent system to replace time-consuming, cost-effective traditional methods. The prepared composites
were structurally analyzed using Fourier Transform Infra-Red spectroscopy (FTIR) and X-ray Diffraction
(XRD) techniques. The morphology and the elemental composition of the nano-biocomposites were
examined using Field Emission Scanning Electron Microscopy (FESEM) and Energy-dispersive X-ray
Spectroscopy (EDX). The in-vitro bioactivity of the bio-composites namely, swelling ratio, biodegradation
and biomineralization ability is monitored in the presence of Simulated Body Fluid (SBF). Our observation demonstrate that silk fibroin concentration influences the formation of hydroxyapatite.

Item Type: Article
Uncontrolled Keywords: Biodegradability Hydroxyapatite Silk fibroin Biomineralization In-situ co-precipitation method
Divisions: PSG College of Arts and Science > Department of Physics
Depositing User: Dr. B Sivakumar
Date Deposited: 16 Aug 2022 06:12
Last Modified: 16 Aug 2022 06:12
URI: https://ir.psgcas.ac.in/id/eprint/1468

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