Santhi, Ramalingam (2020) Immunomodulatory Activity Of Ethyl Acetate Flavonoid Extract Of Thespesia Populnea Leaves In Balb/C Mice. Madras Agricultural Journal - ScienceGate, 107. pp. 21-25.

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Abstract

The immune system is one of the most important biological systems of our body. Immunomodulation is either an increase or decrease in the immune response. To evaluate the immunomodulatory activity of the leaves of Thespesia populnea (Family Malvaceae) in cancer cell line induced Balb/c mice. Various extracts of the leaves of Thespesia populnea (TpFf) were evaluated for the flavonoid content, and the higher content of flavonoid was found to be in ethyl acetate extract and it was used to evaluate the
potential immunomodulatory activity. The ethyl acetate flavonoid extract was
evaluated for immunomodulatory activity in vivo studies, using Balb/c mice
as the animal model. The extract was tested for hematological parameters,
immunological parameters, weight and cellularity of lymphoid organs and
Histopathological observation of spleen and thymus, using sheep red blood
cells (SRBC) as the antigen. PBS served as a control in all the tests. The ethyl
acetate extract exhibited a significant decrease in the WBC and increased in
the RBC and Hb compared to Ehrlich’s lymphoma ascites (ELA) and Dalton’s
lymphoma ascites (DLA) induced groups. It also resulted in a significant
increase in the IL-2, IFN-γ, weight of spleen and thymus and cellularity of
lymphoid organs and malignant changes observed in the DLA and EAC tumorinduced spleen and thymus sections. The ethyl acetate extract was found
to stimulate the immune responses in Balb/c mice induced ELA and DLA.

Item Type: Article
Uncontrolled Keywords: Immunomodulation; ethyl acetate; malvaceae; ELA; DLA.
Depositing User: Mr Team Mosys
Date Deposited: 17 Aug 2022 05:41
Last Modified: 17 Aug 2022 05:41
URI: http://ir.psgcas.ac.in/id/eprint/1478

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