Vinitha, Devaraju and Punam Sen (2022) Curcumin-Based Inhibitors of Thrombosis and Cancer Metastasis Promoting Factor CLEC 2 from Traditional Medicinal Species Curcuma longa. Evidence-Based Complementary and Alternative Medicine: 9344838. pp. 1-14.

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Abstract

(e CLEC-2 receptor protein belongs to the C-type lectin superfamily of transmembrane receptors that have one or more C-type
lectin-like domains. CLEC-2 is a physiological binding receptor of podoplanin (PDPN), which is expressed on specific tumour cell
types and involved in tumour cell-induced platelet aggregation and tumour metastasis. CLEC-2 and podoplanin-expressing
tumour cells interact to increase angiogenesis, tumour development, and metastasis. CLEC-2 is a hemi-immunoreceptor tyrosinebased activation motif (hemi-ITAM) receptor located on platelets and a subset of dendritic cells that are expressed constitutively.
(is molecule is secreted by activated platelets around tumours and has been shown to inhibit platelet aggregation and tumour
metastasis in colon carcinoma by binding to the surface of tumour cells. Pharmacokinetic studies were carried using a DrugLiTo,
and molecular docking was performed using AutoDock Tools 1.5.6 (ADT). Twenty-nine bioactive compounds were included in
the study, and four of them, namely, piperine, dihydrocurcumin, bisdemethoxycurcumin, and demothoxycurcumin, showed
potential antagonist properties against the target. (e resultant best bioactive was compared with commercially available standard drugs. Further, validation of respective compounds with an intensive molecular dynamics simulation was performed using
Schrodinger software. To the best of our knowledge, this is the first report on major bioactive found on clove as natural antagonists ¨
for CLEC-2 computationally. To further validate the bioactive and delimit the screening process of potential drugs against CLEC2, in vitro and in vivo studies are needed to prove their efficacy.

Item Type: Article
Divisions: PSG College of Arts and Science > Department of Microbiology
Depositing User: Mr Team Mosys
Date Deposited: 27 Sep 2022 04:48
Last Modified: 27 Sep 2022 04:48
URI: http://ir.psgcas.ac.in/id/eprint/1549

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