Saikumar, Sathyanarayanan (2022) Toxicity and Antiulcer Properties of Ipomoea wightii (Wall.) Choisy Leaves: An In Vivo Approach Using Wistar Albino Rats. Hindawi Evidence-Based Complementary and Alternative Medicine: 4328571. pp. 1-14.

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Abstract

Humans have been using herbs to prevent and cure various ailments since antiquity, and Ipomoea wightii is a signi�cant medicinal
plant known for its wide ethnobotanical uses. Although the plant is known to treat ulcers, there is no signi�cant scienti�c
validation. e present study aimed to assess the acute toxicity, subacute toxicity, and antiulcer properties of the leaf methanol
extract of I. wightii (IWL). In the subacute study, the extracts were given orally at 100, 200, and 400 mg/kg doses for 28 days, and
we analyzed the biochemical and histological parameters to evaluate the toxicity of IWL. Two dierent models were assessed to
explore antiulcer properties, such as indomethacin- and ethanol-induced ulcer model. Ulcer areas and ulceration percentage
histopathology of the stomach were used to study the ecacy of extracts. e acute toxicity study showed that IWL was safe to the
maximum dose of 2000 mg/kg body weight. In a subacute toxicity study, the oral administration of IWL did not produce any
mortality in the tested animals. e analysis of haematological, liver biochemical, kidney pro�le, lipid pro�le, and in vivo
antioxidant parameters depicted that all the values were within the control limits after the experimental period and were
considered nontoxic to animals. Additionally, the antiulcer study demonstrated a positive response of IWL in a dose-related
manner (indomethacin- and ethanol-induced models). Macroscopic analysis showed that pretreatment with I. wightii leaf
methanol extract signi�cantly reduced the gastric lesion and decreased the ulceration area (14.52 mm2
), demonstrating superior
results to the positive control group (27.71 mm2
). e histopathological analysis revealed that pretreatment with a high dose of
400 mg/kg of I. wightii leaf methanol extract and positive control group (omeprazole) markedly protected pathological eects, and
the gastric mucosa appeared normal. In conclusion, I. wightii has solid nontoxic potential as a promising native herb for an
integral therapy for the treatment of ulcers.

Item Type: Article
Divisions: PSG College of Arts and Science > Department of Botany
Depositing User: Mr Team Mosys
Date Deposited: 06 Oct 2022 09:58
Last Modified: 06 Oct 2022 09:58
URI: http://ir.psgcas.ac.in/id/eprint/1589

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