Anitha Nagarajan, Doss, VA (2024) L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy. L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy, 9 (1). pp. 24-35.

[thumbnail of L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy.pdf] Text
L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy.pdf - Published Version
Download (767kB)

Abstract

Cancer is the second leading cause of death worldwide, and due to the emergence of
resistance to synthetic drugs in different cancers, developing new green drugs have be
come crucial. In this study, chitosan nanoparticles containing Cinnamomum verum J.Presl
essential oil and cinnamaldehyde (major ingredient) were first prepared. The obtained
nanoparticles were then characterized using Dynamic Light Scattering (DLS), Transmis
sion electron microscopy (TEM), and Attenuated Total Reflection-Fourier Transform In
fraRed (ATR-FTIR). After that, anticancer effects of the as-prepared nanoparticles were
investigated. IC50
values of chitosan nanoparticles containing the essential oil were ob
served at 79 and 112 µg/mL against A-375 and MDA-MB-468 cells, respectively. These
values for chitosan nanoparticles containing cinnamaldehyde were obtained at 135 and
166 µg/mL. The results of the current study indicated that chitosan nanoparticles contain
ing C. verum essential oil can inhibit the growth of human melanoma (A-375) and breast
cancer (MDA-MB-468) cells.
Keywords: Chitosan; Cinnamaldehyde; Cinnamomum zeylanicum Blume; Essential oils;
Anticancer activity
*Corresponding Author: Mahmoud Osanloo
Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Scienc
es, Fasa, Iran
Tel/Fax: +9871 53357091
Emails: [email protected] and [email protected]
Citation: Khoshnevisan K, Alipanah H, Baharifar H, Ranjbar N, Osanloo M. Chitosan Nanoparticles Containing Cinnamo
mum verum J.Presl Essential Oil and Cinnamaldehyde: Preparation, Characterization and Anticancer Effects against
Melanoma and Breast Cancer Cells. Trad Integr Med 2022;7(1):1-12.
Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.
org/licenses/by-nc/4.0/). Noncommercial uses of the work are permitted, provided the original work is properly cited.
Abstract
Accepted: 7 Nov 2023
The effect of L-Carvone (a natural monoterpene from Mentha spicata L., leaves) in cardiac hypertrophy caused by iso
proterenol administration was investigated. Male rats (Wistar) were divided into five groups: Control, diseased, diseased
rats with losartan, diseased rats with low-dose L-Carvone, and high-dose L-Carvone. Rats were injected with isoproterenol
(5 mg/kg) for 30 days to induce cardiac hypertrophy. Then, simultaneously with Losartan (15 mg/kg), L-Carvone was
administered orally at a dosage of 25 mg/kg (low dose) and 100 mg/kg (high dose) treatment. The cardioprotective effect
of L-Carvone was evaluated by examining the heart morphometric indices, and ECG analyses. Chronic isoproterenol ad
ministration resulted in changes in morphometric indices of the heart, ECG tracings, biochemical parameters such as tissue
glucose, proteins, lipid profiles, serum cardiac markers, antioxidants, and histopathological integrity of the heart tissue.
When compared with the isoproterenol group, L-Carvone administrated for 30 days ameliorated all these changes in rats

Item Type: Article
Uncontrolled Keywords: on microscopy (TEM), and Attenuated Total Reflection-Fourier Transform In fraRed (ATR-FTIR). After that, anticancer effects of the as-prepared
Divisions: PSG College of Arts and Science > Department of Biochemistry
Depositing User: Dr. B Sivakumar
Date Deposited: 20 Oct 2022 09:35
Last Modified: 17 Nov 2025 08:57
URI: https://ir.psgcas.ac.in/id/eprint/1611

Actions (login required)

View Item
View Item