Victor Arokia Doss, D and Anitha, Nagarajan (2023) L-carvone attenuates myocardial injury and dyslipidemia in rats with isoproterenolinduced cardiac hypertrophy. Asian Pacific Journal of Tropical Biomedicine, 13 (1). pp. 17-25.

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Abstract

Objective: To explore the therapeutic efficacy of L-carvone from
Mentha spicata L. leaf extracts against isoproterenol-induced cardiac
hypertrophy in rats.
Methods: Isoproterenol (5 mg/kg) was injected intraperitoneally
into rats for one month to induce cardiac hypertrophy. L-carvone
(25 and 100 mg/kg) was administered orally to treat cardiac
hypertrophy. The cardioprotective activity of L-carvone was
evaluated by electrocardiogram, histopathological analysis as well as
determination of biochemical parameters and enzymatic markers.
Results: L-carvone from Mentha spicata L. at 25 and 100 mg/kg
ameliorated isoproterenol-induced cardiac hypertrophy, as evidenced
by reduced QRS interval on electrocardiogram, and decreased
heart weight and heart index. In addition, both doses of L-carvone
markedly lowered the levels of glucose, total protein, low-density
lipoprotein cholesterol, aspartate transaminase, alanine transaminase,
lactate dehydrogenase, creatine kinase MB, troponin-Ⅰ, N-terminal
pro-B type natriuretic peptide and triglycerides while increasing
high-density lipoprotein cholesterol and lipase level (P<0.05).
Moreover, L-carvone alleviated contraction band necrosis, and
reorganized the myofibrils with normal striations and myocytes
as well as normal nuclei in cardiac histoarchitecture of rats with
isoproterenol-induced cardiac hypertrophy.
Conclusions: L-carvone from Mentha spicata L. leaf extract can
restore abnormal cardiac function and may be further explored
as a therapeutic agent against the deleterious effects of cardiac
hypertrophy after further evaluation.

Item Type: Article
Uncontrolled Keywords: Cardiac hypertrophy; L-carvone; Dyslipidemia; Myocardial injury; Isoproterenol; Mentha spicata
Depositing User: Mr Team Mosys
Date Deposited: 11 Mar 2023 06:13
Last Modified: 11 Mar 2023 06:13
URI: http://ir.psgcas.ac.in/id/eprint/1756

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