Rajkumar, Mani (2023) One-Pot Hydrothermal Preparation of Hydroxyapatite/Zinc Oxide Nanorod Nanocomposites and Their Cytotoxicity Evaluation against MG-63 Osteoblast-like Cells. Molecules, 28 (345). pp. 1-9.

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Abstract

In the present study, HAp-ZnO nanorod nanocomposites were successfully prepared using
a customized hydrothermal reactor and studied for their compatibility against MG-63 osteoblast-like
cells. The crystallinity, morphology, presence of chemical elements, and surface area properties were
studied by XRD (X-ray diffraction), FE-SEM (field emission scanning electron microscopy), TEM
(transmission electron microscopy), EDS (energy dispersive spectrum) and N2 adsorption/desorption
isotherm techniques, respectively. Further, the mechanical strength and thermal analysis were carried
out using the nanoindentation method and thermogravimetric/differential scanning calorimeter
(TG/DSC) methods, respectively. Moreover, in vitro biocompatibility studies for the prepared samples were carried out against human osteosarcoma cell lines (MG-63). The crystalline nature of the
samples without any impurity phases was notified from XRD results. The formation of composites
with the morphology of nanorods and the presence of desired elements in the intended ratio were
verified using FE-SEM and EDS spectra, respectively. The TG/DSC results revealed the improved
thermal stability of the HAp matrix, promoted by the reinforcement of the ZnO nanorods. The
nanoindentation study ensured a significant enhancement in the mechanical stability of the prepared
composite material. Finally, it demonstrated that the HAp matrix’s mechanical strength and thermal
stability were improved by the reinforcement of ZnO, and the cytotoxicity evaluation affirmed the
biocompatible nature of the biomimetic hydroxyapatite in the composite.

Item Type: Article
Uncontrolled Keywords: hydroxyapatite; zinc oxide; nanocomposite; hydrothermal; biocompatible
Divisions: PSG College of Arts and Science > Department of Physics
Depositing User: Mr Team Mosys
Date Deposited: 11 Mar 2023 07:04
Last Modified: 11 Mar 2023 07:04
URI: http://ir.psgcas.ac.in/id/eprint/1759

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