Vishnupriya, Selvaraj and Sakthivel, K M and Priya Dharshini, Loganathan Chandramani and Rasmi, Rajan Radha (2020) Autophagy markers as mediators of lung injury-implication for therapeutic intervention. Life Sciences. pp. 1-12. ISSN 0024-3205

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Abstract

Lung injury is characterized by inflammatory processes demonstrated as loss of function of the pulmonary capillary endothelial and alveolar epithelial cells. Autophagy is an intracellular digestion system that work as an
inducible adaptive response to lung injury which is a resultant of exposure to various stress agents like hypoxia,
ischemia-reperfusion and xenobiotics which may be manifested as acute lung injury (ALI), acute respiratory
distress syndrome (ARDS), chronic lung injury (CLI), bronchopulmonary dysplasia (BPD), chronic obstructive
pulmonary disease (COPD), asthma, ventilator-induced lung injury (VILI), ventilator-associated lung injury
(VALI), pulmonary fibrosis (PF), cystic fibrosis (CF) and radiation-induced lung injury (RILI). Numerous regulators like LC3B-II, Beclin 1, p62, HIF1/BNIP3 and mTOR play pivotal role in autophagy induction during lung
injury possibly for progression/inhibition of the disease state. The present review focuses on the critical autophagic mediators and their potential cross talk with the lung injury pathophysiology thereby bringing to
limelight the possible therapeutic interventions.

Item Type: Article
Uncontrolled Keywords: Keywords: Lung injury Autophagy Regulators Therapeutics
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 14 Mar 2023 06:56
Last Modified: 14 Mar 2023 06:56
URI: http://ir.psgcas.ac.in/id/eprint/1766

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