Muthukrishnan, P and Nandhini, X and Essam Nageh, Sholkamy and Ashraf, A Mostafa (2020) Antimicrobial and antinematicidal metabolites from Streptomyces cuspidosporus strain SA4 against selected pathogenic bacteria, fungi and nematode. Saudi Journal of Biological Sciences, 27. pp. 3208-3220. ISSN 1319-562X

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Abstract

The exploration of novel therapeutic agents and other bioactive secondary metabolite from Streptomyces
species, for possible agricultural farming, pharmaceutical and industrialized applications, has been, and
still is, essential. The existing studies were aimed with biologically potential Streptomyces species and
its antagonistic activity against dreadful microorganisms. Totally, morphological three different actinomycetes were selected from the fertile agricultural lands. Among the three, the isolate SA4 exhibited significant antimicrobial and anti-nematicidal activity towards selected microbial pathogens such as E
Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Salmonella typhi, Bacillus subtilis, Proteus vulgaris, Shigella flexineri, Candida albicans, and Fusarium sp. The prospective strain SA4 was identified as
Streptomyces cuspidosporus. The isolate SA4 optimized for secondary metabolites production with
International Streptomyces project 4 (ISP 4) medium, pH 7.0 at 37 �C for 14 days. Gas ChromatographyMass spectrometry (GCMS) analysis of strain SA4 bioactive extract publicized the existence of 1,2-
Benzenedicarboxylic acid, bis(2-Methylpropyl) ester compound and occupied by high peak area and its
possessed significant biological properties.

Item Type: Article
Uncontrolled Keywords: Antimicrobial Nematicidal Streptomyces FTIR GCMS
Depositing User: Mr Team Mosys
Date Deposited: 14 Mar 2023 07:05
Last Modified: 14 Mar 2023 07:05
URI: http://ir.psgcas.ac.in/id/eprint/1767

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