Priya Dharshini, Loganathan Chandramani and Rasmi, R R and Sakthivel, K M (2022) Regulatory Components of Oxidative Stress and Infammation and Their Complex Interplay in Carcinogenesis. Applied Biochemistry and Biotechnology.

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Abstract

Cancer progression is closely linked to oxidative stress (OS) infammation. OS is caused
by an imbalance between the amount of reactive oxygen species produced and antioxidants
present in the body. Excess ROS either oxidizes biomolecules or activates the signaling
cascade, resulting in infammation. Immune cells secrete cytokines and chemokines when
infammation is activated. These signaling molecules attract a wide range of immune cells
to the site of infection or oxidative stress. Similarly, increased ROS production by immune
cells at the infamed site causes oxidative stress in the afected area. A review on the role
of oxidative stress and infammation in cancer-related literature was conducted to obtain
data. All of the information gathered was focused on the current state of oxidative stress
and infammation in various cancers. After gathering all relevant information, a narrative
review was created to provide a detailed note on oxidative stress and infammation in cancer. Proliferation, diferentiation, angiogenesis, migration, invasion, metabolic changes,
and evasion of programmed cell death are all aided by OS and infammation in cancer.
Imbalance between reactive oxygen species (ROS) and antioxidants lead to oxidative stress
that damages macromolecules (nucleic acids, lipids and proteins). It causes breakdown
of the biological signaling cascade. Prolonged oxidative stress causes infammation by
activating transcription factors (NF-κB, p53, HIF-1α, PPAR-γ, Nrf2, AP-1) that alter the
expression of many other genes and proteins, including growth factors, tumor-suppressor
genes, oncogenes, and pro-infammatory cytokines, resulting in cancer cell survival. The
present review article examines the complex relationship between OS and infammation in
certain types of cancer (colorectal, breast, lung, bladder, and gastric cancer).

Item Type: Article
Uncontrolled Keywords: Oxidative stress · Infammation · Transcription factors · Cancer · Cytokines
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 15 Mar 2023 09:22
Last Modified: 15 Mar 2023 09:22
URI: http://ir.psgcas.ac.in/id/eprint/1779

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