Saikumar, Sathyanarayanan (2022) Glycogen synthase kinase 3β inhibition and insulin-receptor binding enhancement of compounds isolated from wild leafy vegetable Acalypha alnifolia. Phytomedicine Plus, 2: 100216. ISSN 2667-0313

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Abstract

Background: The traditional information of Acalypha alnifolia is captivate towards its therapeutic efficacy against
diabetes along with the scientific confirmation were leads to an instinct to extract phytocompounds and to
evaluate antidiabetic-molecular mechanism.
Methods: Column chromatographic compound isolation were adopted to extract the pure compounds from
bioactive leaf extract and interactions of the compounds with diabetic metabolic proteins were accomplished
through in-silico docking studies. By the direction, the anti-diabetic property was valued by the expressions of
Glycogen Synthase Kinase 3β(GSK 3β) and Insulin on insulin-Receptor on Hep G2 cells.
Results: The flavone compound - 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-methoxy-4H-chromen-4-one and pyridine
alkaloid - (2,6-dihydroxypyridin-4-yl)(3,5-dihydroxytetrahydro-2H-pyran-4-yl) acetic acid were isolated. Both
the compounds reduced the GSK 3β expression and the flavone contributed also to enhance insulin binding
ability expediently.
Conclusions: The results concluded that the compounds from A. alnifolia having potent to maintain glucose homeostasis in liver insulin-metabolism. By exploring pharmaceutical importance of the isolated compounds, this
study will be an important breakthrough in developing new drug for Diabetes.

Item Type: Article
Uncontrolled Keywords: Acalypha alnifolia Isokaempferide Glycogen synthase kinase 3β Insulin receptor Pyridine alkaloid
Divisions: PSG College of Arts and Science > Department of Botany
Depositing User: Mr Team Mosys
Date Deposited: 16 Mar 2023 05:35
Last Modified: 16 Mar 2023 05:35
URI: http://ir.psgcas.ac.in/id/eprint/1787

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