Rajkumar, Mani (2022) Synthesis of Hydroxyapatite (HAp)-Zirconia Nanocomposite Powder and Evaluation of Its Biocompatibility: An In Vitro Study. Applied Science, 12 (11056). pp. 1-12.

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Abstract

A potential material for dental restorations and bone replacements is calcium phosphate
(CaP)-based ceramic material. Nevertheless, its limited ability to withstand thermal processing and
weak mechanical strength prevents it from being used in hard tissue engineering. Hydroxyapatite
has been extensively used as a CaP-based biomaterial in prosthetic applications. On the other
hand, zirconia is an inorganic material that combines outstanding mechanical capabilities with
bioinert characteristics. In the present investigation, we demonstrated the reinforcement of zirconia
in biomimetic hydroxyapatite (HAp) using a specially designed stir-type hydrothermal reactor to
improve the biocompatibility and mechanical stability of bare hydroxyapatite. X-ray diffraction
(XRD) analysis showed distinct peak shifts around 31◦ and 60◦
, which confirmed the formation
of a nanocrystalline HAp-Zirconia composite without any intermediate phases. The size of the
synthesized nanocomposite was found to be 30 nm using TEM. Further, the d-spacing value calculated
from high-resolution transmission electron microscope (HRTEM) images corresponded to the distinct
planes of the HAp (211) and zirconia (311) phases, respectively, in the composite powder. The
in vitro cytotoxicity study revealed excellent biocompatibility with MG-63 human osteoblasts. Hence,
the zirconia reinforced hydroxyapatite (HZ1) prepared in the present work could be utilized as a
successful approach in a variety of hard tissue engineering applications

Item Type: Article
Uncontrolled Keywords: hydroxyapatite; zirconia; nanocomposite; hydrothermal; biocompatibility
Divisions: PSG College of Arts and Science > Department of Physics
Depositing User: Mr Team Mosys
Date Deposited: 23 Mar 2023 07:15
Last Modified: 23 Mar 2023 07:15
URI: http://ir.psgcas.ac.in/id/eprint/1818

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