Linto Sibi, S P (2021) Ibrutinib conjugated surface-functionalized multiwalled carbon nanotubes and its biopolymer composites for targeting prostate carcinoma. Journal of Material Science, 56. pp. 18684-18696.

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Abstract

In this report, nanocomposites are composed of surface-functionalized multiwalled carbon nanotubes (f-MWCNTs) and polymers (polyethylene glycol,
chitosan) or silver nanoparticles (AgNPs) were successfully synthesized and
used as nanocarriers for drug delivery. The drug (Ibrutinib, Ibr) encapsulated
with different nanocomposites was used for effective prostate cancer treatment.
The as-prepared bioconjugates were confirmed by Fourier transform infrared
spectroscopy, X-ray diffraction, and Raman spectroscopy. The drug loading
efficiency of 95.5% was achieved for f-MWCNTs/AgNPs composite. The drug
release profile showed that the f-MWCNTs/AgNPs composite released 79% in
84 h at pH 5.5 indicating the sustainable drug release. Further, these Ibr-loaded
nanocomposites were conjugated with T30 oligonucleotides (T30 ODN) for targeting over-expressed prostate-specific membrane antigen in the prostate gland.
The prostate anti-cancer activity was evaluated using PC-3 and MDA-MB-231
cancer cells and the results indicated that the Ibr- loaded nanocomposites conjugated with T30 ODN exhibited higher cell killing efficiency compared to the
free Ibr. Therefore, these conjugated nanocomposites are effective drug delivery
systems for prostate cancer disease targeted therapy.

Item Type: Article
Divisions: PSG College of Arts and Science > Department of Physics
Depositing User: Mr Team Mosys
Date Deposited: 28 Mar 2023 06:05
Last Modified: 28 Mar 2023 06:05
URI: http://ir.psgcas.ac.in/id/eprint/1826

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