Victor Arokia Doss, D Cardioprotective activity of Piper betle juice in isoproterenol induced hypertrophic rat models. INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES, 11 (4). pp. 5214-5220. ISSN 0975-7538

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Abstract

Impaired electrolytes (preferably Na+, K+, Cl−, HCO3
−) is one of the key
fundamental complications associated with cardiac hypertrophy (enlarged
heart) mediated heart failure. Piper betle (P. betle - family Piperaceae) due
to its potent antioxidant activity is used in various pharmacological applications. The present study evaluates the cardioprotective (anti-hypertrophic)
potential of aqueous (juice) extract of P. betle in restoring electrolyte homeostasis, thereby its ability to curb the fundamental progression of hypertrophy. Isoproterenol (ISO - 10 mg/kg b.w., i.p., 7 days) induced cardiac hypertrophic rats were developed that were simultaneously treated with the standard drug losartan (50mg/kg b.w., orally., 7days) and aqueous juice extract
of P. betle (30mg/kg b.w., orally., 7 days). The biochemical estimation of
glucose, protein, cholesterol, cardiac marker enzymes like SGOT, SGPT, LDH,
enzymatic antioxidants namely SOD, catalase, GPx and electrolytes (Na+,
K
+, Cl− and bicarbonate) in serum were statistically performed along with
the histopathological analysis of left ventricles (H&E stain). The present
study showed increased levels of glucose, protein, cholesterol, cardiac marker
enzymes, reduced enzymatic antioxidants with reduced electrolytes during
cardiac hypertrophy (ISO) that were reϑlected in a histopathological analysis
by thickened abnormal myocardial architecture which was reversed similar
to normal in plant juice administered rats. Hence, this study demonstrated
the beneϑicial effect of P. betle (aqueous juice) on electrolytes (Na+, K+, Cl−,
HCO3
−), thereby imposing an interventional effect against cardiac hypertrophy

Item Type: Article
Uncontrolled Keywords: Piper betle, isoproterenol, cardiac hypertrophy, serum electrolytes
Depositing User: Mr Team Mosys
Date Deposited: 03 May 2023 05:16
Last Modified: 03 May 2023 05:16
URI: http://ir.psgcas.ac.in/id/eprint/1892

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