HEMALATHA, Devan Exploring the sublethal genotoxic eff ects of class II organophosphorus insecticide quinalphos on freshwater fi sh Cyprinus carpio. Journal of Oceanology and Limnology. pp. 1-10.

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Abstract

The genotoxic eff ects of quinalphos (QP) were evaluated in the erythrocytes of Cyprinus carpio
using the comet, micronucleus, and nuclear abnormality assays. The 96 h LC50 value of quinalphos, estimated
by static renewal system, was 10.9 μL/L. On the basis of the LC50 value, two sublethal concentrations
(1.09 and 2.18 μL/L) of the compound were used together with cyclophosphamide (5 mg/L) as the positive
control. The fi sh were exposed for 35 d, and sampling was done at the end of 7, 14, 21, 28, and 35 d. Our
results reveal a signifi cant dose-dependent increase in the frequencies of DNA strand breaks, micronucleus,
and nuclear abnormalities. Similar responses were also observed in fi sh exposed to the positive genotoxin
cyclophosphamide. The collective fi ndings demonstrated that quinalphos exerts a genotoxic eff ect on C .
carpio . The results further confi rmed that the comet, micronucleus, and nuclear abnormality assays are
useful tools in determining the potential genotoxicity of pesticides towards aquatic organisms.

Item Type: Article
Uncontrolled Keywords: quinalphos (QP); micronucleus; nuclear abnormalities; cyclophosphamide; Cyprinus carpio
Divisions: PSG College of Arts and Science > Department of Zoology
Depositing User: Mr Team Mosys
Date Deposited: 05 Jul 2023 08:55
Last Modified: 05 Jul 2023 08:55
URI: http://ir.psgcas.ac.in/id/eprint/1960

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