Nagarajan, Anitha (2023) L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy. L-Carvone from Mentha spicata L. Leaves Suppresses Oxidative Stress and Hypertrophy in the Isoproterenol-Induced Rat Model of Cardiac Hypertrophy, 9 (1). pp. 24-35.

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Abstract

The effect of L-Carvone (a natural monoterpene from Mentha spicata L., leaves) in cardiac hypertrophy caused by iso�proterenol administration was investigated. Male rats (Wistar) were divided into five groups: Control, diseased, diseased
rats with losartan, diseased rats with low-dose L-Carvone, and high-dose L-Carvone. Rats were injected with isoproterenol
(5 mg/kg) for 30 days to induce cardiac hypertrophy. Then, simultaneously with Losartan (15 mg/kg), L-Carvone was
administered orally at a dosage of 25 mg/kg (low dose) and 100 mg/kg (high dose) treatment. The cardioprotective effect
of L-Carvone was evaluated by examining the heart morphometric indices, and ECG analyses. Chronic isoproterenol ad�ministration resulted in changes in morphometric indices of the heart, ECG tracings, biochemical parameters such as tissue
glucose, proteins, lipid profiles, serum cardiac markers, antioxidants, and histopathological integrity of the heart tissue.
When compared with the isoproterenol group, L-Carvone administrated for 30 days ameliorated all these changes in rats
significantly (p < 0.05). L-Carvone adequately averted chronic cardiac hypertrophy, most probably through its antioxidant
potential.

Item Type: Article
Uncontrolled Keywords: M. spicata L.; L-Carvone; Antioxidant; Cardioprotective; Antihypertrophic
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 16 Apr 2024 09:38
Last Modified: 16 Apr 2024 09:38
URI: http://ir.psgcas.ac.in/id/eprint/2119

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