Pichai Nalini and Kalibulla Syed Ibrahim and Durairaj Brindha (2021) In vitro evaluation and molecular docking analysis of potential anticancer compounds from Annona muricata L. In vitro evaluation and molecular docking analysis of potential anticancer compounds from Annona muricata L..

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Abstract

Annona muricata L. is widely distributed in tropical and subtropical regions around the world.
Traditionally this plant has been used as a medicine for multiple ailments including cancer. The present
study focussed on the anticancer activities of hydroethanolic extracts of leaves of A. muricata L. on
Dalton’s Lymphoma Ascites (DLA) cell line in comparison with standard drug doxorubicin. Cytotoxicity
studies have indicated that the phytoconstituents of A. muricata have the ability to selectively target
cancer cells (IC50 = 185.585 µg/ml), whereas minimal or negligible cytotoxic effects were observed on
normal cells. Gas Chromatography - Mass Spectrometry data revealed the presence of 16
phytoconstituents comprising mainly alkaloids and phenolic compounds. Pharmacokinetic profi ling and
molecular docking studies using the phytoconstituents were performed in order to gain a better
understanding of the putative mechanisms of action leading to the development of improved and
affordable therapies.

Item Type: Article
Uncontrolled Keywords: Annona muricata L., Anticancer, Dalton's Lymphoma Ascites, NAT2, COX2, p53, Molecular Docking
Divisions: PSG College of Arts and Science > Department of Biotechnology
Depositing User: Mr Team Mosys
Date Deposited: 20 Aug 2024 06:52
Last Modified: 20 Aug 2024 06:52
URI: https://ir.psgcas.ac.in/id/eprint/2170

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