Mohan das, S (2021) Effects of Two Isolated Compounds from Red Sorghum Bran on p53 and bcl 2 Gene Expression in Human Breast cancer Cell Line (MCF-7). Effects of Two Isolated Compounds from Red Sorghum Bran on p53 and bcl 2 Gene Expression in Human Breast cancer Cell Line (MCF-7).

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Abstract

Aims: The aim of our research was to isolate anthocyanin from red sorghum bran and to study its effects
on p
53 and bcl 2 gene expressions in Human Breast cancer cell line (MCF-7).
Main methods: Two compounds were isolated from red sorghum bran by using Sephadex LH-20 column
chromatography. The antiproliferative activity of isolated compounds were analysed by MTT assay and
the expression studies were performed by RT-PCR analysis.
Key fi ndings: Our research focusing on apigenin-5-β-D-glucopyranoside and luteolin-5-β-D�glucopyranoside another compound as a potention anticancer agent have demonstrated that the
compounds isolated from red sorghum bran inhibited breast cancer cell lines by up regulation of P
53
gene expression and down regulation of Bcl 2 gene expression.
Signifi cance: In conclusion, the two compounds isolated from red sorghum bran, were effective in up
regulation of P
53 and down regulation of Bcl 2 gene expression.

Item Type: Article
Uncontrolled Keywords: Apigenin-5-β-D-glucopyranoside, MCF – 7 cell line, red sorghum bran
Depositing User: Mr Team Mosys
Date Deposited: 23 Aug 2024 07:42
Last Modified: 23 Aug 2024 07:42
URI: https://ir.psgcas.ac.in/id/eprint/2172

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