Sreeram, S and Arunprasath, A and Revathi, P (2021) In-Silico Studies on Selected Active Constituents of Corbichonia decumbens Against Allergic Bronchopulmonary Aspergillosis. In-Silico Studies on Selected Active Constituents of Corbichonia decumbens Against Allergic Bronchopulmonary Aspergillosis. ISSN 2693-5015

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Abstract

Herbs have been employed in the treatment of various diseases and other medicinal purposes for a long time and
they’ve been the zest of our life. Corbichonia decumbens an erect, short-lived succulent herb is found to possess
zenith medicinal properties. At a first, the in-silico activity of the plant has been determined to carry out a
modification in the Surfactant Protein-D (SP-D) which plays a pivotal role in defense against the Allergic
Bronchopulmonary Aspergillosis (ABPA). The SP-D protein has been modified using in-silico tools thus making
it more robust in containing ABPA. The protein SP-D when combined with the plant compound 1-methyl-3,5-
dinitro-1,2,4-triazole had binding energy of -6.98 and interactions with active site residue ASN-236, LYS-246,
GLU-232, PHE-234 and, GLN-236. Being one of the first in-silico works carried out in this plant species it aims
to provide a substantial base for future works and unwrap the potential of this herb in all aspects of medicinal
plant science

Item Type: Article
Uncontrolled Keywords: In-silico, Herb Medicine, Herb-drug interaction, Docking Approach, ABPA
Divisions: PSG College of Arts and Science > Department of Botany
Depositing User: Mr Team Mosys
Date Deposited: 11 Sep 2024 09:12
Last Modified: 11 Sep 2024 09:12
URI: https://ir.psgcas.ac.in/id/eprint/2253

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