Senthil Kumar, J (2025) Polydimethylsiloxane loaded capsaicin afflicts membrane integrity, metabolic activity and biofilm formation of nosocomial pathogens. Polydimethylsiloxane loaded capsaicin afflicts membrane integrity, metabolic activity and biofilm formation of nosocomial pathogens, 200.
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Abstract
Biofilms constitute 80% of all nosocomial infections associated with invasive medical devices.
Polydimethylsiloxane, a silicone polymer widely used as implants, suffers from microbial
adhesion. Inhibition of biofilm formation on PDMS surfaces is significant to prevent morbidity,
mortality and replacement. The present study investigates the efficacy of capsaicin (0.5% w/v)
loaded PDMS as a broad spectrum antimicrobial surface against Staphylococcus aureus,
Escherichia coli and Candida albicans. Capsaicin exhibited minimum inhibitory concentration
(MIC) of 1024 µg mL-1 for S. aureus, E. coli and 256 µg mL-1 for C. albicans. Capsaicin
inhibited biofilms of S. aureus, E. coli and C. albicans at much lower concentrations of 2, 64 and
8 µg mL-1 respectively. The minimum capsaicin concentrations required for total biofilm
eradication (MBEC) was found to be 256, 512, 128 µg mL-1 for S. aureus, E. coli and C. albicans
respectively. Probing sub-lethal concentrations (64 µg mL-1) of capsaicin revealed 38, 32, 30%
reduction in metabolic activity of S. aureus, E. coli & C. albicans planktonic cells respectively.
Similarly, there was an increase in permeability of cells to propidium iodide compared to control.
By reducing the metabolic activity and perturbing membrane integrity, capsaicin could prevent
biofilm formation and this was also observed with capsaicin-PDMS surfaces that exhibited 1 log
(~90%) reduction of viable bacterial counts.
Item Type: | Article |
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Uncontrolled Keywords: | Capsaicin, Polydimethylsiloxane, antibiofilm, Membrane damage, nosocomial pathogens. |
Divisions: | PSG College of Arts and Science > Department of Biotechnology |
Depositing User: | Mr Team Mosys |
Date Deposited: | 27 May 2025 04:35 |
Last Modified: | 27 May 2025 04:35 |
URI: | https://ir.psgcas.ac.in/id/eprint/2426 |