Muthukrishnan, P and Rajendran Ramasamy (2025) Assessment of Antimicrobial Activity and Determination of Phytochemical Constituents of Herbs Used in Burn Wound Treatment. Assessment of Antimicrobial Activity and Determination of Phytochemical Constituents of Herbs Used in Burn Wound Treatment. pp. 1-24. ISSN 2693-5015

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Abstract

Burn wounds can be invasive as well as non-invasive as they are frequently exposed to microbial infections and
this can lead to development of several complications as patients affected with burn wounds are in the state of
immune suppression. Also, nosocomial infections play a major role in infecting the burn wounds. Apart from
nosocomial infections, emerging multi-drug resistant microorganisms such as Methicillin-Resistant
Staphylococcus aureus (MRSA) also contribute to burn wound infections. The development of fungal infections in
burn wounds is caused by Candida albicans and Aspergillus sp., as they possess higher resistance to conventional
azoles. To overcome the multi-drug resistance complication, the present study deals with screening of those
herbal extracts that can treat burn wounds and microbial infections associated with them e ciently. The herbs
collected for screening in this study were Rosmarinus o cinalis, Myristica fragrans, Nigella sativa and
Chrysopogon zizanoides. On completion of antimicrobial activity assessment, it was observed that Rosmarinus
o cinalis and Myristica fragrans possessed highest antimicrobial activity and were further used for in the form of
combinatorial herbal extract. In case of combinatorial herbal extract highest antibacterial activity was observed
against Klebsiella pneumoniae (19 mm) and combinatorial herbal extract showed activity against all the bacterial
strains and in case of fungi the highest antifungal activity was against Candida albicans (16 mm). Apart from
e cient antimicrobial activity both the extracts had e cient antioxidant activity which is required for wound
healing also phytochemicals were present in a considerable quantity in ethanolic extracts of Rosmarinus
o cinalis and Myristica fragrans.

Item Type: Article
Uncontrolled Keywords: Burn wounds, Microbial infections, Rosmarinus o cinalis, Myristica fragrans, Nigella sativa and Chrysopogon zizanoides
Divisions: PSG College of Arts and Science > Department of Microbiology
Depositing User: Mr Team Mosys
Date Deposited: 26 Sep 2025 09:10
Last Modified: 26 Sep 2025 09:10
URI: https://ir.psgcas.ac.in/id/eprint/2443

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